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目的 探讨榄香烯治疗神经胶质瘤的临床效果。方法 胶质瘤患者 4 9例 ,分榄香烯单药治疗组 1 6例 ,榄香烯与化疗药物联合治疗组 33例。榄香烯注射剂量成人 1 0 0 0mg/d ,颈总动脉和外周静脉交替使用 2 0天为 1个疗程。比较用药前后肿瘤体积变化、临床表现、生存期并评价毒副作用。结果 榄吞烯颈总动脉注射和外周静脉滴注 ,总有效率为 4 6 94 % (CR 1 4 2 9% ,PR 32 6 5 % ) ,肿瘤平均缩小 30 89%± 5 5 97% ,临床症状有不同程度好转 ,32例患者进行生存期统计 <1年 7例 ,>1年 1 4例 ,>2年 6例 ,>3年 5例。榄香烯单独应用有效率为 37 5 % ,联合用药组 1可达到 5 1 .5 1 %。而且该药无骨髓抑制、胃肠道反应等毒副作用。结论 榄香烯抗胶质瘤的疗效确切。在临床应用中需注意用药剂量要充足 ,用药时间要足够长 ,用药途径尽可能选择经动脉给药。榄香烯可常规应用于胶质瘤病人 ,宜早期使用 ;对于经其他方法治疗无效的病人也可作为尝试性治疗
Objective To investigate the clinical efficacy of elemene in the treatment of glioma. Methods Forty-nine patients with glioma were divided into elemene monotherapy group (n = 16) and elemene combined with chemotherapy drug group (n = 33). Elemene injection dose of adult 1OOmg / d, common carotid artery and peripheral vein alternately 20 days for a course of treatment. Before and after treatment of tumor volume changes, clinical manifestations, survival and evaluation of toxic and side effects. Results The total effective rate was 4 694% (CR 1 42 29%, PR 32 65%). The average tumor shrinkage was 30 89% ± 5 5 97% Symptoms improved to varying degrees, 32 patients with survival statistics <1 year in 7 cases,> 1 year in 14 cases,> 2 years in 6 cases,> 3 years in 5 cases. The effective rate of elemene alone was 37.5%, and the combination group 1 reached 51.51%. And the drug without bone marrow suppression, gastrointestinal reactions and other toxic side effects. Conclusion The efficacy of elemene against glioma is exact. In clinical applications should pay attention to dosage should be adequate, medication time should be long enough, the route of administration as much as possible through the artery. Elemene can be routinely used in patients with glioma, should be used early; for patients who have been ineffective by other methods can also be used as a trial treatment