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目的通过临床药师对围手术期抗菌药物使用的监控与管理,评价其实施的效果。方法采用回顾性调查方法,对本院2012年5~6月和2013年5~6月行乳腺手术337例的资料进行统计与分析。将前者177例作为非干预组,后者200例作为干预组,比较临床药师干预抗菌药物预防性使用的效果。结果与非干预组相比,乳腺手术干预组围手术期抗菌药物预防用药的适应证由59.9%提高到89.5%,选择合理性由74.6%提高到100.0%,用法用量使用合理性由69.5%提高到91.0%,首次用药时机合理性由55.9%提高到93.0%,术后用药疗程合理性由58.2%提高到95.0%;平均住院费用、平均住院天数也显著下降(P<0.05)。结论通过临床药师有效的干预,围手术期抗菌药物预防使用的合理性得到了显著提高。
Objective To evaluate the efficacy of clinical pharmacists in the monitoring and management of perioperative antibacterials use. Methods A retrospective survey was conducted to analyze and analyze the data of 337 cases of breast surgery from May to June in 2012 and from May to June in 2013 in our hospital. 177 cases of the former as a non-intervention group and 200 cases of the latter as an intervention group, comparing the clinical pharmacist interventions for the preventive use of antibacterial drugs. Results Compared with the non-intervention group, the indications for the prophylactic use of antimicrobial agents during the perioperative period in the breast surgery intervention group increased from 59.9% to 89.5%, the selection rationality increased from 74.6% to 100.0%, and the rationality of the usage dosage increased from 69.5% To 91.0%. The rationality of the first medication was improved from 55.9% to 93.0%, and the rationality of postoperative medication was improved from 58.2% to 95.0%. The average cost of hospitalization and the average length of hospital stay also dropped significantly (P <0.05). Conclusion The rational use of antimicrobial agents in perioperative period has been significantly improved by the effective intervention of clinical pharmacists.