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多环芳烃类是广泛存在的污染物。实验发现,许多多环芳烃可抑制体液免疫,而不抑制在抗肿瘤免疫中起主要作用的细胞免疫。体液免疫的抑制包括抗原引起的B细胞增殖与抗体合成的抑制。抑制作用与组织Ah受体有关。此外,还取决于给药途径,药代学等。最近发现DMBA及MCA可抑制细胞免疫及NK细胞的活力,B(a)P则没有这一作用。目前,上述免疫抑制作用的细胞机制仍不清
Polycyclic aromatic hydrocarbons are widespread pollutants. It has been found experimentally that many polycyclic aromatic hydrocarbons inhibit humoral immunity without inhibiting cellular immunity that plays a major role in antitumor immunity. Inhibition of humoral immunity includes antigen-induced inhibition of B cell proliferation and antibody synthesis. Inhibition is related to tissue Ah receptor. In addition, depending on the route of administration, pharmacokinetics and more. Recently, DMBA and MCA were found to inhibit cellular immunity and NK cell viability, but B (a) P did not. At present, the cellular mechanism of the above immunosuppressive effects is still unclear