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1958年Nelson首先报道了双侧肾上腺增生的Cushing综合征(Cushing病)患者行双侧肾上腺手术后,发生明显的皮肤色素沉着垂体腺瘤,血浆ACTH及MSH(黑色素细胞刺激素)浓度明显升高,称为Nelson综合征。现将我们遇到的一例报告如下。王××,女,35岁,住院号96718。主诉:视力减退半年,双目失明2个月。患者进行性发胖以胸背躯干为主,怕热多汗,体毛增多,血压进行性升高,头疼4年,于1974年被诊断为Cushing综合征行双侧肾上腺部分切除术,病理证实为增生。术后血压恢复正常,口服强的松三个月后皮肤逐渐变
In 1958, Nelson first reported that after bilateral adrenal surgery in patients with bilateral adrenal hyperplasia in Cushing’s syndrome (Cushing’s disease), there was a clear pituitary adenoma with pigmentation. The plasma concentrations of ACTH and MSH (melanocyte stimulating hormone) were significantly increased. , called Nelson syndrome. We now report an example of what we have encountered below. Wang × ×, female, 35 years old, hospital number 96718. Chief Complaint: Visual loss for half a year and blindness for 2 months. Subjects with progressively obese chest-dorsal trunks, with fear of hot sweating, increased body hair, progressively elevated blood pressure, and headache for 4 years, were diagnosed with Cushing syndrome bilateral partial adrenalectomy in 1974. Pathology confirmed hyperplasia . Blood pressure returned to normal after surgery, and the skin gradually changed after oral administration of prednisone