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目的:探讨南京部分地区女性人乳头瘤病毒(HPV)感染的型别和年龄特征,为宫颈癌的防治提供参考资料。方法:采用人乳头状瘤病毒的基因扩增技术(HPV PCR)对2010年9月至2011年7月3382例就诊于南京妇幼保健院宫颈疾病科的女性进行HPV基因亚型检测,21种型别包括15种高危型和6种低危型,分析比较上述样品的感染程度、感染型别、感染年龄等。结果:HPV总阳性率为33.47%(1132/3382),21种型别均被检出,该地区女性阳性率最高的型别是HPV16,其他常见为58、52、CP8304、53、18、33等,多重感染率为9.58%。该地区女性HPV阳性率与各年龄组无显著差异(P>0.1)。结论:该地区女性HPV阳性率为33.47%,常见型别为HPV16、58、52、CP8304、53、18、33、68、31、39、11、6和66型;人群感染存在在<20岁和>70岁两个高峰。
Objective: To investigate the types and age characteristics of female human papillomavirus (HPV) infection in some areas of Nanjing and provide references for the prevention and treatment of cervical cancer. Methods: HPV genotypes were detected in 3382 women who visited the cervical disease department of Nanjing Maternal and Child Health Hospital from September 2010 to July 2011 by using HPV PCR. Do not include 15 kinds of high-risk and 6 kinds of low-risk type, analysis and comparison of the above samples of the level of infection, type of infection, age of infection and so on. Results: The total positive rate of HPV was 33.47% (1132/3382). Twenty-one of the 21 types were detected. The highest positive rate of HPV16 in this area was HPV16, while the others were 58,52, CP8304, 53, 18, and 33 The multiple infection rate was 9.58%. There was no significant difference in the HPV positive rate among women in this area (P> 0.1). Conclusion: The positive rate of HPV in this area is 33.47%. The common types are HPV16,58,52, CP8304,53,18,33,68,31,39,11,6 and 66. The infection in the population is less than 20 years And> 70 years old two peaks.