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目的了解感染登革病毒后特异性抗体产生规律和血液常规的变化情况,为临床正确诊治提供实验依据。方法随机选取广州市1次登革热暴发疫情中2014年10月至11月收治的485例登革病毒抗体检测阳性且同时进行血液常规检测的发热患者,登革病毒非结构蛋白的Ig M/Ig G抗体检测采用胶体金法,血液常规检测采用XN3000全自动血液分析流水线。结果 485例患者中,登革病毒Ig M抗体(DV-Ig M)阳性290例(59.79%),DVIg M和登革病毒Ig G抗体(DV-Ig G)同时阳性者84例(17.32%),DV-Ig G阳性者111例(22.89%)。有218例(44.95%)和42例(8.66%)患者白细胞分别<3.5×109/L和<2.0×109/L。DV-Ig M阳性组白细胞水平最低,与DV-Ig G阳性组比较差异有统计学意义(P<0.05)。有258例(53.20%)和46例(9.49%)患者血小板分别<125×1012/L和<50×1012/L,DV-Ig M阳性组血小板水平分别低于Ig M+Ig G阳性组(P<0.05)及Ig G组(P<0.01)。结论登革病毒抗体和血液常规检测可为登革病毒感染的早期、快速、正确的诊治提供实验依据,临床医生应对白细胞<2.0×109/L和血小板<50×1012/L的重症患者引起足够的重视。
Objective To understand the regularity of antibody production and routine changes of blood after dengue virus infection and provide experimental evidence for clinical diagnosis and treatment. Methods One hundred and sixty-five cases of dengue virus were randomly selected from one outbreak of Dengue outbreak in Guangzhou from October 2014 to November 2014. The patients with fever who were positive for Dengue virus antibody test and blood routine examination at the same time were enrolled. Ig M / Ig G Antibody detection using colloidal gold method, routine blood testing using XN3000 automatic blood analysis pipeline. Results Among the 485 cases, 84 cases (17.32%) were positive for dengue virus Ig M antibody (DV-Ig M) positive in 290 cases (59.79%) and DVIg M and dengue virus Ig G antibody (DV- , 111 cases (22.89%) had DV-Ig G positive. There were 218 (44.95%) and 42 (8.66%) patients with leukocytes <3.5 × 109 / L and <2.0 × 109 / L, respectively. The leukocyte level in DV-Ig M positive group was the lowest, which was significantly different from that in DV-Ig G positive group (P <0.05). There were 258 cases (53.20%) and 46 cases (9.49%) with platelet counts <125 × 1012 / L and <50 × 1012 / L, respectively. The platelet count of DV-Ig M positive group was lower than that of Ig M + Ig G positive group P <0.05) and Ig G group (P <0.01). Conclusion Dengue virus antibodies and routine blood tests can provide experimental evidence for early, rapid and correct diagnosis and treatment of dengue virus infection. Clinicians should respond adequately to severe patients with white blood cells <2.0 × 109 / L and platelets <50 × 1012 / L The importance of.