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目的探讨P21、nm23-H1与食管癌浸润和转移的关系。方法应用免疫组织化学法,检测食管癌P21和nm23-H1的表达。结果P21和nm23-H1在食管癌中的阳性率分别为55.0%和63.3%。P21与浸润深度相关,nm23-H1与淋巴结转移相关。结论P21和nm23-H1可作为判断食管癌浸润和转移的指标之一。
Objective To investigate the relationship between P21, nm23-H1 and the invasion and metastasis of esophageal cancer. Methods Immunohistochemistry was used to detect the expression of P21 and nm23-H1 in esophageal cancer. Results The positive rates of P21 and nm23-H1 in esophageal cancer were 55.0% and 63.3% respectively. P21 and depth of invasion, nm23-H1 and lymph node metastasis. Conclusion P21 and nm23-H1 can be used as indicators of the invasion and metastasis of esophageal cancer.