论文部分内容阅读
利用气相层析和放射免疫法测定了10例使用甲地孕酮硅橡胶阴道环(下称硅甲环)妇女尿中的E_1、E_2、E_3、P_2和LH 的含量,并用光学显微镜观察了子宫内膜的变化。实验证明10例使用硅甲环妇女中:有7例排卵,尿中LH、E_1、E_2、E_3和P_2的分泌曲线与正常组相似,但分泌总量减少,尿中三种雌激素的比例为E_3>E_1>E_2,该组的子宫内膜虽属分泌期,但腺体发育较差;2例不排卵,LH、E_1、E_2、E_3和P_2不出现典型的分泌曲线;另1例不排卵兼有突破性出血,尿中LH、E_1、E_2、E_3及P_2的分泌量在整个周期中波动甚大,三种雌激素的比例异常,这类不排卵型的子宫内膜仍处于增生期。本工作表明硅甲环对妇女下丘脑—垂体—性腺轴的影响较小,其避孕环节主要是影响卵泡的发育和黄体的正常功能。
The contents of E_1, E_2, E_3, P_2 and LH in urine of 10 women who received vaginas of megestrol silicone ring were measured by gas chromatography and radioimmunoassay. The uterus was observed by light microscopy Endometrial changes. Experiments show that 10 cases of women with silicone ring: 7 cases of ovulation, urinary LH, E_1, E_2, E_3 and P_2 secretion curve similar to the normal group, but the total secretion decreased urinary estrogen ratio was E_3> E_1> E_2. Although the endometrium of this group was secretory stage, the glandular body developed poorly; 2 cases did not ovulate, LH, E_1, E_2, E_3 and P_2 did not show the typical secretion curve; Both breakthrough bleeding, urinary LH, E_1, E_2, E_3 and P_2 secretion throughout the entire cycle fluctuations, the proportion of three estrogen abnormalities, such non-ovulation type endometrium is still in the proliferative phase. This work shows that the silicon ring on the female hypothalamus - pituitary - gonadal axis smaller, the main aspects of its contraception affect the development of follicles and the normal function of the corpus luteum.