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冠状动脉硬化性心脏病(CAHD)病因的研究很少涉及环境毒物。本文根据有关资料将讨论CAHD可能的环境病原学因素。 一、一氧化碳 吸烟时一氧化碳和尼古丁很可能是CAHD的致病因子。猴和兔短期接触一氧化碳后(COHB:10～21％)均发生动脉硬化,饲料中同时加入胆固醇,则其动脉硬化更加明显。Wald曾指出,COHB的水平超过5％的吸烟者患动脉硬化性心脏病的危险性为同年龄性别的COHB低于3％的吸烟者的20倍。 芬兰通过对大量铸工的调查发现,心绞痛发病率在不接触一氧化碳的不吸烟的人群中为2％,而在接触一氧化碳的吸烟者中为19％。一氧化碳接触增多,随之发生原有CAHD的恶化。周围空气中一氧化碳增多时,心肌梗塞
Studies of the etiology of coronary heart disease (CAHD) rarely involve environmental toxicants. This article based on the information will be discussed CAHD possible environmental etiological factors. First, carbon monoxide and nicotine smoking is likely to be causative agent of CAHD. After the short-term exposure to carbon monoxide in monkeys and rabbits (COHB: 10 ~ 21%) were atherosclerosis, while adding cholesterol in the feed, then the atherosclerosis is more obvious. Wald pointed out that smokers with COHB levels above 5% are at 20 times more likely to have atherosclerosis heart disease than smokers with COHB below 3% at the same age. Finnish surveys of large numbers of foundry workers found that the incidence of angina was 2% in non-smokers without carbon monoxide and 19% among smokers exposed to carbon monoxide. Increased carbon monoxide exposure, followed by the deterioration of the original CAHD. Increased carbon monoxide in the air around, myocardial infarction