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通常认为免疫球蛋白重链(IgH)基因的表达是通过V_H启动子和定位于J_H-C_H内含子的增强子联合调节的.但有些细胞系缺乏此内含子-增强子,仍能转录IgH基因。这提示在IgH座位上还存在其它
It is generally believed that the expression of immunoglobulin heavy chain (IgH) genes is regulated by the combination of the V_H promoter and the enhancer located on the J_H-C_H intron.1 However, some cell lines lack this intron-enhancer and are still capable of transcription IgH gene. This suggests there are other things on the IgH seat