曼氏血吸虫保护性和非保护性表膜碳水化合物表位的特征

• 作 者: 王建军
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1990年02期
• 关键词: 血吸虫 膜抗原 单克隆抗体 表膜 表位 候选抗原 曼氏血吸虫 被动转移 宿主免疫应答 童虫

体外许多试验证明在血吸虫发育中,对宿主的各种效应机制敏感的血吸虫表膜抗原是宿主免疫应答的靶抗原。用抗血吸虫表膜抗原的单克隆抗体被动转移免疫的结果亦表明表膜抗原与保护作用密切相关,因此,血吸虫表膜抗原很可能是研制血吸虫疫苗的候选抗原。然而,被动免疫的结果同时表明,并非所有单克隆抗体均具保护作用,保护力似乎与抗体的表型无关。为了检查单克隆抗体之

Many in vitro tests have demonstrated that schistosome epidermal antigens, which are sensitive to various host-induced mechanisms of action, are the target antigens of the host’s immune response during schistosomal development. Passive immunization with monoclonal antibodies against schistosoma surface antigen also showed that the epidermal antigens are closely related to the protective effect. Therefore, the schistosome epidermal antigen is likely to be a candidate antigen for the development of schistosome vaccine. However, the results of passive immunization also showed that not all monoclonal antibodies are protective and the protective power seems to be independent of the antibody’s phenotype. In order to check the monoclonal antibody