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采用酶联免疫吸附测定法对３２例肾移植患者、１２０例原发性高血压患者和８０例正常人尿免疫球蛋白Ｇ、Ａ、Ｍ（ＩｇＧ、ＩｇＡ、ＩｇＭ）及微量白蛋白（Ａｌｂ）的２４ｈ排泄量和清除率进行测定，结果发现肾移植患者２４ｈ排泄量和清除率明显高于高血压组、正常组（Ｐ＜０．０１～０．００１），认为ＩｇＧ、ＩｇＡ、ＩｇＭ及Ａｌｂ的２４ｈ排泄量和清除率增高与慢性排异反应、ＣｓＡ肾毒性有关，可作为排异反应、ＣｓＡ肾毒性早期诊断条件，对判定临床治疗效果有一定指导意义。
Enzyme linked immunosorbent assay was used to detect urinary immunoglobulin G, A, M (IgG, IgA, IgM) and microalbumin (Alb) in 32 renal transplant recipients, 120 essential hypertension patients and 80 healthy controls. 24h excretion and clearance were measured and found that renal transplant recipients 24h excretion and clearance rate was significantly higher than the hypertensive group, normal group (P <0.01 ~ 0.001), that IgG, IgA, IgM and Alb 24h excretion and clearance rate increased with chronic rejection, CsA nephrotoxicity, can be used as rejection, CsA nephrotoxicity early diagnosis conditions, to determine the clinical treatment effect of some guidance.