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目的 探讨心肌缺血预处理（ＩＰＣ）保护该心肌被以后较长时间缺血损伤的作用。方法 给Ｗｉｓｔａｒ大鼠在９０ｍｉｎ缺血和１８０ｍｉｎ再灌注（Ｉ／Ｒ）前３次、每次５ｍｉｎ、间隔５ｍｉｎ再灌注的心肌缺血预处理；Ｉ／Ｒ前静脉注射Ｂｒｅ．、ＰＭＡ观察它们对心肌Ｉ／Ｒ损伤的影响作用。结果 ＩＰＣ、ＰＭＡ可保护心肌被Ｉ／Ｒ的损伤；Ｂｒｅ．则可消除ＩＰＣ对心肌的保护作用。结论 ＩＰＣ可保护心肌被长达９０ｍｉｎ．Ｉ／１８０ｍｉｎ．Ｒ损伤，其保护机制作者正在研究之中，可能与蛋白激酶Ｃ被激活有关。
Objective To investigate the effect of myocardial ischemic preconditioning (IPC) on myocardial ischemia after a long period of time. Methods Wistar rats were pretreated with myocardial ischemic preconditioning at 90 min ischemia and 3 min before I / R 180 min, 5 min reperfusion at intervals of 5 min. , PMA observed their impact on myocardial I / R injury. Results IPC and PMA could protect myocardium from I / R injury. Bre. You can eliminate the protective effect of IPC on the myocardium. Conclusion IPC protects myocardium for up to 90 min. I / 180min. R injury, the protection mechanism of which the author is studying, may be related to protein kinase C is activated.