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维生素B_6(简称B_6)是临床上常用的一种药物,以治疗B_6缺乏症、呕吐、帕金森氏病、回乳、贫血和中毒性粒细胞缺乏症、动脉粥样硬化症、VB_6遗传性缺陷等[1]疾病。随着本品使用的日趋广泛,与其他药物配合使用在增多。我们从中发现一些值得注意的问题。现列举实例以阐述其合理与不合理配伍的机理以及预防措施。一、VB_6与某些药物的药理性配伍问题 1.VB_6与异烟肼的配伍:B_6对异烟肼抑制结核杆菌的效果有明显对抗作用,可影响它们的疗效。故常规服用异烟肼,一般不宜口服B_6。另外在开始服用异烟肼1～2个月时,可不必配伍B_6因食物中可有来源。而在中后期的服药过程中,B_6可逐步消耗较多,故有时需配伍少量B_6,但由于异烟肼为抗结核杆菌的首选药物,对各种结核杆菌有高度选择性作用。由于结核杆菌的抗药之故,临床用药时不得不加大用量,延长疗程,但这样又易产
Vitamin B_6 (referred to as B_6) is a clinically used drug to treat B_6 deficiency, vomiting, Parkinson’s disease, reflux, anemia and toxic neutropenia, atherosclerosis, VB_6 genetic defects Etc. [1] Diseases. With the use of this product is becoming more widespread, with the use of other drugs in increasing. We find some noteworthy issues. Now give examples to illustrate its rational and unreasonable compatibility mechanism and preventive measures. First, VB_6 pharmacological compatibility with some drugs Problem 1.VB_6 and isoniazid compatibility: B_6 on isoniazid inhibition of Mycobacterium tuberculosis significantly antagonistic effect, can affect their efficacy. Therefore, taking isoniazid conventional, generally should not be oral B_6. Also start taking isoniazid 1 to 2 months, may not need to be compatible with B_6 because there may be sources of food. In the course of taking medicine in the later period, B_6 can gradually consume more, it is sometimes necessary to be compatible with a small amount of B_6, but because isoniazid is the drug of choice for anti-tuberculosis bacilli, a variety of Mycobacterium tuberculosis highly selective role. Due to the resistance of Mycobacterium tuberculosis, the clinical medication had to increase the dosage to extend the course of treatment, but it is easy to produce