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以前认为肿瘤坏死因子（ＴＮＦ）是一种很有希望杀死肿瘤细胞的物质，有实验证明可缩小肿瘤组织。近几年来研究证明，ＴＮＦ不能直接杀死肿瘤细胞，确切地说ＴＮＦ不能单独对肿瘤细胞有杀伤作用，而是通过抑制细胞核因子κＢ（ＮＦκＢ）使肿瘤细胞死亡。ＮＦκＢ是一种ｐ５０和ｐ６５组成的异源双体，其活性还受到强抑制物ＩκＢ的控制。ＮＦκＢ在维持组织细胞的生死平衡、炎症反应和肿瘤治疗中的细胞凋亡起到调控作用，肿瘤治疗中的细胞因子、放疗和化疗药物都需通过ＮＦκＢ才能起作用，故认为其对肿瘤的治疗有潜在作用
It was previously thought that tumor necrosis factor (TNF) is a promising material for killing tumor cells, and experiments have shown that it can shrink tumor tissue. In recent years, studies have shown that TNF can not directly kill tumor cells, specifically TNF can not kill tumor cells alone, but by inhibiting nuclear factor κB (NF κB) to make tumor cells die. NF-κB is a heterodimer composed of p50 and p65, and its activity is also controlled by the strong inhibitor IκB. NFκB plays a regulatory role in maintaining the balance of life and death of tissue cells, inflammatory response and apoptosis in tumor therapy. Cytokines, radiotherapy and chemotherapy drugs in tumor therapy all need to work through NFκB, so they are considered Potential role in the treatment of cancer