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单用强地松或并用硫唑嘌呤治疗重症非病毒性慢性活动性肝炎可使病情缓解,并有助于提高该病生存率。然而,治疗所需时间较长,包括复治在内,累计用药时间长达5年余。免疫抑制剂长期应用可致恶性肿瘤发生。本文研究目的是了解免疫抑制剂治疗重症乙肝表面抗原(HBsAg)阴性慢性活动性肝炎,肝外恶性肿瘤的发生率及相关因素。病人与方法:收集20年间,149 例病人,均满足以下条件,(1)无乙型肝炎病毒感染;(2)否认同性恋及非法药物、肝脏毒性药物应用和输血治疗等;(3)单用强地松或并用硫唑嘌呤累计时间至少6个月者。其中46例单用强地松治疗,每日20mg;103例联合用药,强地松每日10mg 加硫唑嘌呤每日50mg。病人长期用药,直
Single prednisone or combined azathioprine treatment of severe non-viral chronic active hepatitis can ease the disease and help to improve the survival rate of the disease. However, treatment takes longer, including retreatment, the cumulative treatment time up to more than 5 years. Long-term use of immunosuppressive agents can cause malignant tumors. The purpose of this study is to understand the immunosuppressant treatment of severe hepatitis B surface antigen (HBsAg) negative chronic active hepatitis, the incidence of extrahepatic malignancies and related factors. Patients and Methods: During the 20 years of collection, 149 patients met the following criteria: (1) no hepatitis B virus infection; (2) denial of homosexual and illegal drugs, use of hepatotoxic drugs and blood transfusions; (3) Strong pine or with azathioprine cumulative time of at least 6 months. 46 cases were treated with prednisone alone, daily 20mg; 103 cases combined with prednisone daily 10mg plus azathioprine 50mg daily. Long-term use of the patient, straight