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传统上把肠道易激综合征(IBS)、非心源性胸痛(NCCP)等功能性消化道疾病归为以收缩力过强为特征的动力(motilty)性疾病。自长时间监测食管及结肠后,对动力引起这些疾病的各种症状的作用发生了怀疑。同时发现NCCP、IBS及非溃疡性消化不良患者对内脏感觉刺激的阈值下降。在IBS患者常有自律神经功能失调的症状,如软弱、心悸、头昏、掌跖潮红及反射活跃。本文将讨论NCCP及IBS患者内脏感觉传入机制可能有变化,首先介绍目前对内脏感觉机制的概念。内脏传入机制胃肠道有副交感及交感神经双重外源性神经支配,神经干含有传递自CNS到内脏信息的传出纤维及传递从内脏到CNS的传入(感觉)
Traditionally, functional gastrointestinal diseases such as irritable bowel syndrome (IBS) and non-cardiac chest pain (NCCP) have been classified as motilty diseases characterized by excessive contractility. After prolonged monitoring of the esophagus and the colon, doubts have been cast on the effects of motility on the various symptoms of these diseases. Also found NCCP, IBS and non-ulcer dyspepsia in patients with visceral sensory threshold decreased. In IBS patients often have symptoms of autonomic dysfunction, such as weakness, palpitations, dizziness, palms and flushing and reflex activity. This article will discuss possible mechanisms of visceral afferent afferent changes in patients with NCCP and IBS. The concept of the visceral perception mechanism is first introduced. Visceral afferent mechanism The gastrointestinal tract has parasympathetic and sympathetic dual extrinsic innervations. The neural stem contains afferent fibers that transmit from the CNS to the visceral information and transmits the afferent (sensation) from the viscera to the CNS.