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目的探讨放疗治疗局部晚期鼻咽癌患者的临床疗效。方法选取2011年1月至2012年4月抚顺矿务局总医院收治的80例局部晚期鼻咽癌初治患者作为研究对象,按随机数字表法将其分为观察组和对照组,各40例。对照组患者采用同期放疗联合化疗进行治疗,观察组患者仅行单纯放射治疗,比较两组患者的生存情况及不良反应发生情况。结果两组患者的3年无区域复发生存率、无局部复发生存率、无瘤生存率及无远处转移生存率差异均无统计学意义(均P>0.05);观察组患者黏膜反应、消化道反应、皮肤反应、白细胞降低发生率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论单纯放疗治疗局部晚期鼻咽癌患者的近期疗效与放疗同期化疗的疗效相近,且不良反应少。
Objective To investigate the clinical effects of radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods From January 2011 to April 2012, 80 patients with locally advanced nasopharyngeal carcinoma treated by General Hospital of Fushun Mining Bureau were selected as the research object and divided into observation group and control group according to the random number table method example. Patients in the control group were treated with concurrent radiotherapy combined with chemotherapy. Patients in the observation group were treated with simple radiotherapy alone. The survival and adverse reactions of the two groups were compared. Results There was no significant difference in the three-year regional recurrence-free survival rate, no local recurrence survival rate, tumor-free survival rate and distant metastasis-free survival rate between the two groups (all P> 0.05). The mucosal reaction and digestion The incidences of tract reaction, skin reaction and leukopenia were significantly lower than those of the control group (all P <0.05). Conclusions The short-term curative effect of simple radiotherapy for locally advanced nasopharyngeal carcinoma is similar to that of concurrent radiotherapy, with fewer adverse reactions.