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正常肝脏的血供25％来自肝固有动脉,75％来自门静脉,而肝癌的血流则90％来自肝固有动脉。故肝癌与正常肝组织这种血液供应上的差别,为肝动脉插管灌注化疗药提供了治疗基础。本文选用DFM方案(DDP、MMC、5—FU或5—FUDR)行肝动脉灌注治疗20例晚期肝癌,取得较为满意疗效,现总结如下: 一、临床资料 20例中男性15例,女性5例;年龄最大为79岁,最小为32岁;1例肝癌伴肺转移,5例肝癌伴轻中度腹水,10例伴有不同程度黄疸,4例B超提示门脉癌栓存在。AFP阳性14例,火箭电泳>400ng/ml10例;HAA阳性10例,6例有乙肝病史,16例有饮酒史。二、插管方法采用seldinger氏法,经皮股动脉穿刺插管。用7号进口导管,远端加工成“C”型,在穿刺成功后先插入进口金属导丝,然
25% of the blood supply to normal liver comes from the hepatic artery, 75% from the portal vein, and 90% of the blood flow from liver cancer comes from the proper hepatic artery. Therefore, the difference in blood supply between liver cancer and normal liver tissue provides therapeutic basis for infusion of chemotherapeutic drugs into the hepatic artery. This article selected DFM program (DDP, MMC, 5-FU or 5-FUDR) for hepatic artery perfusion treatment of 20 cases of advanced liver cancer, achieved satisfactory results, are summarized as follows: First, the clinical data of 20 cases of 15 males and 5 females The oldest is 79 years old, the smallest is 32 years old; 1 case of hepatocellular carcinoma with lung metastasis, 5 cases of hepatocellular carcinoma with mild to moderate ascites, 10 cases with different degrees of jaundice, 4 cases of B-mode ultrasound prompted the presence of portal vein tumor thrombus. AFP was positive in 14 cases, rocket electrophoresis was >400 ng/ml in 10 cases, HAA was positive in 10 cases, 6 cases had a history of hepatitis B, and 16 cases had a history of drinking. Second, intubation method using seldinger’s method, percutaneous femoral artery puncture cannulation. With the No. 7 inlet catheter, the distal end is processed into a “C” shape. After the puncture is successful, the imported metal guide wire is inserted first.