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近年由于制药工业的蓬勃发展,各种化学合成药物或生物制剂充塞市场,药品泛滥,服药成灾。医学科学家在20世纪70年代攻克癌肿的征途中,在观察到药物种种不良反应的同时也注意到了药品与医疗措施对人类的体细胞和生殖细胞遗传结构的潜在影响。 60年代初,发生了震惊世界的反应停(thalidomide)致畸胎事件之后,药物致畸作用才引起人们的重视。因而在60年代中期,美国和世界卫生组织已先后制订了控制药物致畸的条例。70年代初Herbst证实:孕妇由于服用二乙基己烯雌酚(diethylstibestrol)而导致其下一代的官颈或阴道透明细胞癌,因
In recent years due to the vigorous development of the pharmaceutical industry, a variety of chemical synthetic drugs or biological stuff stuffed the market, drugs flooding, medication disaster. While observing the adverse effects of drugs during the conquest of cancer in the 1970s, medical scientists also noted the potential impact of drugs and medical interventions on the somatic and germline genetic structures of humans. After the thalidomide teratogenic event that shocked the world in the early 1960s, the teratogenic effects of drugs have attracted much attention. Therefore, in the mid-1960s, the United States and the World Health Organization have successively enacted regulations to control the teratogenicity of drugs. Herbst Confirmation in Early 70s: Pregnant women due to diethylstibestrol caused their next generation of cervical or vaginal clear cell carcinoma due to