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目的 探索适用于我国农村地区癫痫患者的有效治疗方法,并进一步验证其推广应用价值。方法 在山西晋城泽州县及河南焦作市武陟县两个农村社区人群中选定全身强直-阵挛型发作的活动性癫痫患者376人(山西185例,河南191例)。由经过短期培训的乡村医生按照规定方案使用苯巴比妥单药治疗、管理病人,并观察疗效、患者的依从性及药物不良反应。结果 治疗观察1年的效果表明,服药7～12个月期间与入组前半年的情况比较,有45.9％的患者未再发作,发作频度减少>75％者占15％,两项合计显效率为60.9％。在规定剂量内无明显副作用。结论 本研究再次证明,该方案适合在我国广大农村地区进一步推广应用,可使约半数癫痫患者受益。
Objective To explore effective treatment methods for epilepsy patients in rural areas in China and to further verify the value of its application. Methods 376 active epilepsy patients (185 cases in Shanxi and 191 cases in Henan province) were selected from two rural communities in Zezhou County, Jincheng, Shanxi Province and Wuzhi County, Jiaozuo City, Henan Province. Short-term training by rural doctors in accordance with the provisions of the program using phenobarbital monotherapy, management of patients, and observe the efficacy, patient compliance and adverse drug reactions. Results The results of one-year observation showed that 45.9% of the patients in the first 7 months of treatment took no more seizures than those in the first 6 months of treatment, the frequency of episodes decreased by 75% or 15% Efficiency is 60.9%. No significant side effects in the prescribed dose. Conclusion This study proved once again that this program is suitable for further popularization and application in the vast rural areas in China, which can benefit about half of epilepsy patients.