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目的:分析复治菌阳肺结核患者采用环丙沙星联合化疗治疗的临床效果。方法:选择我院于2012年11月至2014年5月期间收治的64例复治菌阳肺结核患者作为分析对象,随机分为观察组和对照组,各32例。对照组患者给予3Hl Zk/6Hl E方案化疗,观察组在对照组治疗基础上增加环丙沙星治疗,比较两组患者的治疗效果。结果:菌阴转率:观察组痰集菌阴转率、痰结核菌培养阴转率均显著高于对照组,组间差异p<0.05。X线胸片变化:观察组肺部病灶吸收率、空洞闭合率显著高于对照组,组间差异p<0.05。不良反应:观察组不良反应发生率与对照组比较,无显著差异p>0.05。结论:复治菌阳肺结核患者采用环丙沙星联合化疗治疗,可显著提高其临床疗效,且该疗法安全性较高,应推广使用。
Objective: To analyze the clinical effect of ciprofloxacin combined with chemotherapy in patients with relapsing bacilli and pulmonary tuberculosis. Methods: Sixty-four patients with convalescent pulmonary tuberculosis treated in our hospital from November 2012 to May 2014 were randomly divided into observation group and control group, with 32 cases in each group. Patients in the control group were given 3H1 Zk / 6Hl E chemotherapy. The observation group was given ciprofloxacin on the basis of the control group, and the treatment effect was compared between the two groups. Results: The rate of bacterial vaginosis: the sputum collection negative conversion rate in the observation group and the sputum TB culture negative conversion rate were significantly higher than those in the control group, with a difference of p <0.05. X-ray changes: The observation group lung lesions absorption rate, void closure rate was significantly higher than the control group, the difference between groups p <0.05. Adverse reactions: adverse reactions in the observation group compared with the control group, no significant difference p> 0.05. Conclusion: The combination of ciprofloxacin and chemotherapy in retreatment of positive pulmonary tuberculosis patients can significantly improve its clinical efficacy, and the safety of the therapy is high and should be widely used.