论文部分内容阅读
尽管重症肌无力(MG)的确切病因还不甚清楚,但大多数学者认为,MG发病主要与自身AchRab引起骨骼肌运动终板乙酰胆碱受体减少或功能异常有关。通过应用人骨骼肌抗原和改进实验技术,全身型MG病人血清AchRab的阳性率已提高到90％左右,但仍有10～15％的全身型和30～50％的眼肌型MG病人血清AchRab始终阴性。因而目前许多学者均把这类MG称为“血清抗体阴性的重症肌无力”。
Although the exact etiopathogenisis of myasthenia gravis (MG) is unclear, most scholars believe that the pathogenesis of MG is mainly related to the reduction or dysfunction of acetylcholine receptor of end-stage skeletal muscle caused by its own AchRab. Through the application of human skeletal muscle antigen and improved experimental techniques, the positive rate of serum AchRab in patients with systemic MG has been raised to about 90%, but there are still 10 to 15% of the whole body and 30 to 50% of patients with ocular MG, serum AchRab Always negative. Therefore, many scholars at the moment regard this type of MG as “serum antibody-negative myasthenia gravis.”