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Objective:To investigate the existence of pericryptal fibroblasts sheath(PCFS) in normal gastric mucosa, intestinal metaplasia(IM),indefinite for dysplasia(I-Dys),low grade dysplasia(L-Dys),high grade dysplasia(H-Dys) and gastric cancer(GC),and its association with gastric carcinogenesis. Methods:In this study,we examined the existence of PCFS in normal gastric mucosa(N=10),IM(N=26),I-Dys (N=16),L-Dys(N=13),H-Dys(N=21) and GC(N=145) using immunohistochemical staining for two smooth muscle markers,alpha smooth muscle actin(α-SMA) and high molecular weight caldesmon(h-CD).The significance of PCFS was discussed,especially in association with gastric carcinogenesis. Results:The PCFS was recognized in 65.4%(17/26) of IM,62.5%(10/16) of I-Dys and 23.1%(3/13) of L-Dys respectively.No PCFS was detected in H-Dys and GC.The PCFS was gradually reduced in IM,Dys and GC in sequence(P<0.0001). Conclusion:The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.
Objective: To investigate the existence of pericryptal fibroblasts sheath (PCFS) in normal gastric mucosa, intestinal metaplasia (IM), indefinite for dysplasia (I-Dys), low grade dysplasia (L-Dys) Methods: In this study, we examined the existence of PCFS in normal gastric mucosa (N = 10), IM (N = 26), I-Dys ), L-Dys (N = 13), H-Dys (N = 21) and GC (N = 145) using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin (alpha- SMA) and high molecular weight caldesmon Results: The PCFS was recognized in 65.4% (17/26) of IM, 62.5% (10/16) of I-Dys and 23.1% (3/13) of L-Dys respectively. PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence (P <0.0001). Conclusion: The PCFS was associated with the differentiation of epithelium and involved in gastric carcinoge nesis via epithelial-mesenchymal interaction.