论文部分内容阅读
目的研究早期高容量血液滤过对重症急性胰腺炎(SAP)的影响。方法将2004年8月至2007年11月南昌大学第一附属医院消化科收治30例重症急性胰腺炎患者随机分为两组:早期高容量血滤组和对照组。治疗前后比较患者急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、肝肾功能、血气分析、炎症介质(TNF-α、IL-1)、抗炎介质(IL-10)浓度。结果早期高容量血液滤过治疗开始前和治疗后血清尿素氮(BUN)、肌酐(Cr)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)均明显下降,动脉血氧分压(PaO2)和氧合指数(PaO2/FiO2)均有明显提高,血浆TNF-α、IL-1、IL-10均有显著下降。结论早期高容量血液滤过治疗能平衡患者内环境,是SAP治疗的一项有效方法。
Objective To study the effect of early high-volume hemofiltration on severe acute pancreatitis (SAP). Methods Thirty patients with severe acute pancreatitis admitted to the Department of Gastroenterology, the First Affiliated Hospital of Nanchang University from August 2004 to November 2007 were randomly divided into two groups: early high-capacity hemofiltration group and control group. Before and after treatment, APACHEⅡ score, liver and kidney function, blood gas analysis, inflammatory mediators (TNF-α and IL-1) and anti-inflammatory mediators (IL-10) were compared. Results Serum urea nitrogen (BUN), creatine (Cr), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly decreased before and after high-volume hemofiltration in early stage. (PaO2) and oxygenation index (PaO2 / FiO2) were significantly increased, plasma TNF-α, IL-1, IL-10 were significantly decreased. Conclusion Early high-volume hemofiltration therapy can balance the patient’s internal environment is an effective method of SAP treatment.