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近年来,抗生素种类越来越多,但常见抗生素引起的肾损伤少见,本文进行综述。 1 大环内酯类 麦迪霉素、螺旋霉素、红霉素等肾毒性虽小,但剂量过大用药时间长或联合用药时可发生肾损伤,主要引起肾间质小管急性炎症,表现为蛋白尿镜下血尿等,一般无肾功能BUN升高表现。但有人认为与原发性疾病引起水代谢紊乱有关。老年人或肾功不良者易发生耳毒性听力下降。 2 喹诺酮类 喹诺酮类抗生素为近年来发展很快的抗菌药物,治疗范围广,副作用少。由于该药大部分以原形经肾脏排泄对肾功能有一定损害,有报道老年肺部感染用环丙沙星治疗,出现血Bun升高,停药6d降至正常;环丙沙星治疗急性肠炎引起Bun为14.9
In recent years, more and more types of antibiotics, but rare common renal damage caused by antibiotics, this article is reviewed. 1 macrolide Midecamycin, spiramycin, erythromycin and other nephrotoxicity is small, but overdosage medication for a long time or combination can occur when renal injury, mainly caused by acute renal interstitial inflammation, manifested as Proteinuria, hematuria, etc., generally without renal function increased BUN performance. However, some people think that with the primary disease caused by water metabolism disorders. Elderly or renal dysfunction prone to ototoxicity hearing loss. 2 quinolones Quinolones antibiotics for the rapid development of antibacterial drugs in recent years, the treatment of a wide range of side effects. Since most of the drug is excreted by the kidneys, the renal function has been impaired. It is reported that the elderly pulmonary infection was treated with ciprofloxacin and the increase of blood Bun was found. After stopping the drug for 6 days, the blood was returned to normal. Ciprofloxacin was used to treat acute enteritis Cause Bun to be 14.9