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目的探讨胰腺癌不同治疗方式与临床疗效及预后的关系。方法将2000年1月至2006年12月收治的45例胰腺癌患者的临床资料进行回顾性分析,用COX比例风险模型对可能影响胰腺癌疗效的指标进行多因素分析,并用Kaplan-Meier法计算生存率。结果总有效率CR+PR为82.2%);1,2年生存率分别为24.4%和8.9%;中位生存期8个月。单因素分析显示,Karnofsky评分、肿瘤位置、CA-199、是否手术、临床分期、治疗情况、近期疗效、CBR与治疗疗效存在相关性。多因素分析显示,Karnofsky评分≥70分;CA-199疗前升高,治疗后恢复正常者;近期疗效达CR/PR者可望提高生存率。结论 Karnofsky评分、CA-199、近期疗效是影响胰腺癌预后的因素。
Objective To investigate the relationship between different treatment methods and clinical efficacy and prognosis of pancreatic cancer. Methods The clinical data of 45 patients with pancreatic cancer admitted from January 2000 to December 2006 were analyzed retrospectively. Multivariate analysis was performed on the indicators that may influence the efficacy of pancreatic cancer by COX proportional hazard model. Kaplan-Meier method was used to calculate Survival rate. Results The total effective rate CR + PR was 82.2%). The 1-year and 2-year survival rates were 24.4% and 8.9% respectively. The median survival time was 8 months. Univariate analysis showed that Karnofsky score, tumor location, CA-199, whether surgery, clinical stage, treatment, short-term efficacy, CBR and treatment efficacy are related. Multivariate analysis showed that Karnofsky score ≥70 points; CA-199 increased before treatment, normalized after treatment; the recent effect of CR / PR is expected to improve the survival rate. Conclusions Karnofsky score, CA-199, short-term efficacy is the prognostic factor of pancreatic cancer.