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自1991年9月至1992年10月,以氟嗪酸(Ofloxacin)治疗伤寒105例,现将其临床疗效、毒副反应总结报道如下。 1 临床资料 105例,男性44例,女性61例。年龄最小15岁,最大62岁。平均年龄29岁,其中15～30岁70例,占66.7％,31～45岁30例,占28.5％,46～62岁5例,占4.76％。所有病例经流行病学细菌学检查确诊。所有病例均有发热,其中>40℃57例,肝脏肿大64例,脾脏肿大38例,血红蛋白尿3例,并发肠出血者5例,精神障碍者1例,血谷丙转氨酶48～160U(本院正常值<40U)18例。药物剂量与服法:氟嚓酸200mg,8小时1次,疗程2周。
From September 1991 to October 1992, 105 cases of typhoid fever were treated with Ofloxacin, and its clinical efficacy and side effects were summarized as follows. A clinical data of 105 cases, 44 males and 61 females. Youngest 15 years old, maximum 62 years old. The average age was 29 years, of which 70 cases were 15-30 years old, accounting for 66.7%, 30 cases were 31-45 years old, accounting for 28.5% and 5 cases were 46-62 years old, accounting for 4.76%. All cases were confirmed by epidemiological bacteriological examination. All cases were fever, including> 40 ℃ 57 cases, 64 cases of liver enlargement, 38 cases of splenomegaly, hemoglobinuria in 3 cases, 5 cases of intestinal bleeding, mental disorders in 1 case, blood alanine aminotransferase 48 ~ 160U (Normal hospital <40U) in 18 cases. Drug dose and service method: Vitamizole 200mg, 8 hours 1, treatment for 2 weeks.