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本文观察了某托儿所于1981年春～1982年秋Ⅲ型轮状病毒的3次暴发流行和1989年春1次Ⅰ型轮状病毒暴发流行以及最近试用口服活疫苗的效果,其初步结果如下:(1)具保护力的病毒血清型特异性。1981～1982年Ⅲ型轮状病毒暴发流行中双份血清中和试验(荧光灶减数法)和临床情况分析观察的结果:初次血清效价≤1:32者,24/26发病;≥1:128者,1/23发病。病后对同型病毒抗体明显上升,对异型病毒的抗体效价稍有上升,不明显。据此,保护力与型特异的中和抗体效价密切相关;(2)交叉免疫保护力存在的可能性。Ⅲ型轮状病毒流行中双份
In this paper, we observed three outbreaks of rotavirus type Ⅲ and 1 rotavirus type Ⅰ rotavirus in a nursery school in the spring of 1981 ~ 1982 and a recent trial of oral live vaccine. The preliminary results are as follows: (1) Protective virus serotype specificity. In 1981 ~ 1982 type Ⅲ rotavirus outbreak epidemic in double serum neutralization test (Focal lesion method) and the clinical analysis of the results of the observation: initial serum titer ≤ 1:32, 24/26 incidence; ≥ 1 : 128, 1/23 of the disease. After the onset of disease, the antibody to the same type of virus increased significantly, and the antibody titer of the variant virus increased slightly, not obvious. Therefore, the protective effect is closely related to the type-specific neutralizing antibody titer. (2) The possibility of cross-immunity protection exists. Type III rotavirus in duplicate