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致畸学研究常可通过动物实验,以评价测试物的潜在胚胎毒性、胎儿毒性和致畸作用。而致畸作用是籍以对胎仔的外部、内脏和骨胳等检查后,才能作出判断。因此,正确的检查方法,是获得可靠结果的关键。过去,检查内脏畸形的惯用方法是Wilson徒手切片法。Staples认为,该法由于组织在Bouin溶液中的自溶,固定和切片时的人为因素,可影响观察结果。因此,他提出了用新鲜标本作内脏畸形检查的方法。该
Teratology studies can often pass animal experiments to evaluate the potential embryotoxicity, fetal toxicity and teratogenicity of the test article. The teratogenic effect is based on the fetus on the outside, visceral and skeletal check, to make judgments. Therefore, the correct method of inspection is the key to obtaining reliable results. In the past, the usual method of examining visceral malformations was Wilson’s hand-slicing method. According to Staples, the method can affect the observation because of the human factors in tissue autolysis, fixation and sectioning in Bouin’s solution. Therefore, he proposed using fresh specimens for examination of visceral malformations. This