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1965年,Baldwin 等首次报导了青霉素和新青霉素Ⅰ引起急性间质性肾炎(AIN),并发展为急性肾功能衰竭。已有报导,20多种药物可引起 AIN,进而导致急性肾功能衰竭。在反应次数和重要性两方面,青霉素族抗菌药物均居首位。可能是由于临床普遍应用青霉素,容易导致这类损害。羧苄青霉素,新青霉素Ⅱ,新青霉素Ⅲ,氨苄青霉素,最近还有羟氨苄青霉素都与AIN 有关。而先锋霉素族中β-内酰胺环抗菌结构也被认为可引起 AIN 或加重由青霉素引起的肾损害因素。由青霉素引起的 AIN,它的临床表现近10年来变
In 1965, Baldwin et al. First reported that penicillin and penicillin Ⅰ caused acute interstitial nephritis (AIN) and developed acute renal failure. It has been reported that more than 20 kinds of drugs can cause AIN, leading to acute renal failure. Penicillin family antibacterials rank the first place in the number and importance of reactions. May be due to widespread clinical use of penicillin, easily lead to such damage. Carbenicillin, penicillin II, penicillin III, ampicillin, and more recently, amoxicillin are related to AIN. The antibacterial structure of the β-lactam ring in the cephalosporin family is also thought to cause AIN or aggravate the renal impairment caused by penicillin. AIN caused by penicillin, its clinical manifestations have changed over the past 10 years