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肺小细胞癌肿是一种能产生激素和生物活性物质的肿瘸。降钙素是最常见的一种激素。本文研究肺小细咆癌病人降钙索变化的临床价值。方法和结果肺小细胞癌的病人24例中,弥散性病变19例,局限性5例,所有病人均经二个疗程化疗,然后用2000Rad 作预防性脑部照射。脑部有转移的病人同时用3000 Rad 照射脑部,以后再用化疗巩固,一直至缓解,完全缓解的病人再进行原发病灶的放疗。19例弥散性病人中男17例、女2例。平均年龄62(49～78)岁。其中男性61.6岁,女性65.5岁。经治疗后,所有病人均取得缓解。5例完全缓解48周,1例缓解超过66周。在治疗期间,所有病人肾功能正常,只1例血清钙大于10.5mg/100ml(正常范围9～10.4mg/100ml)。病变广泛的病例,降钙素平均浓度为233±37pg/ml,范围27～82.5pg/ml(正常≤100pg/ml)。部分或完全缓解的病人,血浆降钙素平均降低至57pg/ml P<0.001。9例复发的病人血浆
Pulmonary small cell carcinoma is a lame that produces hormones and bioactive substances. Calcitonin is the most common hormone. This study was to study the clinical value of the changes of calcitonin in patients with small cell carcinoma of lung. Methods and Results Of the 24 patients with small cell lung cancer, 19 were diffuse lesions and 5 were localized. All patients were treated with two cycles of chemotherapy and then were treated with 2000 Rad for prophylactic brain irradiation. At the same time, the patient with brain metastasis was irradiated with 3000 Rad and the brain was solidified with chemotherapy until the patients with complete remission were treated with radiotherapy of primary lesion. 19 cases of diffuse patients, 17 males and 2 females. The average age of 62 (49 ~ 78) years old. Among them, males are 61.6 years old and females are 65.5 years old. After treatment, all patients were relieved. Five patients had complete remission for 48 weeks and one patient had remission for more than 66 weeks. During treatment, all patients had normal renal function, with only 1 serum calcium greater than 10.5 mg / 100 ml (normal range 9 to 10.4 mg / 100 ml). Extensive cases of disease, calcitonin average concentration of 233 ± 37pg / ml, the range of 27 ~ 82.5pg / ml (normal ≤ 100pg / ml). Patients with partial or complete remission had an average reduction of plasma calcitonin to 57 pg / ml P <0.001.9 of patients relapsed