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在生物医学研究工作中,为了减少和避免实验动物个体间差异所造成的影响,常常需要用近交系动物做实验。目前全世界各国实验室维持和使用的小鼠近交系及其亚系至少在250种以上,曾被广泛道选用于遗传、免疫、肿瘤、代谢、内分泌等各方面的研究。但易于感染约氏疟原虫的小鼠品系,国内外报道极少。疟疾为我国常见病之一,也是军事医学研究的重点项目,防疟有助于提高部队的战斗力,具有战略意义。为了开展人类疟疾病因和防治实验研究,需要建立约氏疟原虫敏感近交系。SMMC/C小鼠是我校建立的第一个对约氏疟原虫敏感的近交系动物。在培育过程中,某些生物学特性已表现出相对稳定,也受到医
In biomedical research, it is often necessary to experiment with inbred animals to reduce and avoid the effects of differences among laboratory animals. At present, more than 250 inbred strains and their subfamilies are maintained and used in laboratories all over the world. They have been extensively used in studies of genetics, immunology, oncology, metabolism, endocrinology and so on. But easy to infect Plasmodium yoelii mouse strains, very few reports at home and abroad. Malaria is one of the most common diseases in our country and is also a key project of military medical research. It is of strategic importance that anti-malaria helps to increase the combat effectiveness of the troops. In order to carry out experimental studies on the etiology and control of human malaria, it is necessary to establish a sensitive inbred line of Plasmodium yoelii. SMMC / C mice were the first inbred line animals in our school to be sensitive to Plasmodium yoelii. Some biological characteristics have shown relatively stable during cultivation and have also been treated