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目的评价超声引导下射频消融(radio frequency ablation,RFA)联合无水乙醇注射(percutaneousethanol injection,PEI)治疗危险部位肝癌的临床应用价值。方法危险部位肝癌患者43例随机分为2组,对照组16例给予RFA治疗,观察组27例给予RFA联合PEI治疗,比较2组治疗后危险部位病灶完全坏死率、并发症发生率及同组危险部位与中央部位病灶完全坏死率。结果观察组与对照组危险部位病灶完全坏死率分别为92.6%,56.3%,差异有统计学意义(P<0.01);观察组危险部位病灶完全坏死率与中央部位病灶完全坏死率比较差异无统计学意义(P>0.05),对照组差异有统计学意义(P<0.05)。观察组并发症发生率(3.7%)低于对照组(25.0%),差异有统计学意义(χ2=4.434,P=0.048)。结论 RFA联合PEI治疗危险部位肝癌安全、有效。
Objective To evaluate the clinical value of ultrasound-guided radio frequency ablation (RFA) combined with percutaneousethanol injection (PEI) in the treatment of liver cancer at risk. Methods Forty-three patients with hepatocellular carcinoma at risk were randomly divided into two groups, 16 patients in the control group received RFA, 27 patients in the observation group received RFA combined with PEI. The complete necrosis rate, complete complication rate, The risk of complete necrosis of the central part of the site of disease and necrosis. Results The complete necrosis rates of the lesions in the observation group and the control group were 92.6% and 56.3%, respectively, with significant difference (P <0.01). There was no statistical difference between the complete necrosis rate of the lesion and the complete necrosis of the lesion in the central part of the observation group Significance (P> 0.05), the difference between the control group was statistically significant (P <0.05). The incidence of complications in the observation group (3.7%) was lower than that in the control group (25.0%), the difference was statistically significant (χ2 = 4.434, P = 0.048). Conclusion The combination of RFA and PEI in the treatment of liver cancer in dangerous sites is safe and effective.