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目的探讨他汀类联合心血管药物治疗冠心病的治疗效果。方法 78例冠心病患者,随机分为观察组和对照组,各39例。对照组使用心血管药物治疗,观察组使用他汀类联合心血管药物治疗。比较两组患者的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果治疗后,观察组患者TC为(4.21±0.17)mmol/L、TG为(1.24±0.21)mmol/L、HDL-C为(2.28±1.02)mmol/L、LDL-C为(2.87±1.27)mmol/L,均优于对照组的(4.95±0.95)、(1.75±0.26)、(3.01±1.41)、(3.34±1.48)mmol/L,差异具有统计学意义(P<0.05)。观察组患者在治疗期间未出现与他汀类药物相关的不良反应,患者依从性较好,安全性较高。结论采用他汀类联合心血管药物治疗冠心病的治疗效果明显,安全性较高,值得在临床上推广。
Objective To investigate the effect of statins combined with cardiovascular drugs in the treatment of coronary heart disease. Methods 78 patients with coronary heart disease were randomly divided into observation group and control group, 39 cases each. The control group was treated with cardiovascular drugs and the observation group was treated with statins and cardiovascular drugs. The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were compared between the two groups. Results After treatment, TC in the observation group was (4.21 ± 0.17) mmol / L, TG was (1.24 ± 0.21) mmol / L, HDL-C was (2.28 ± 1.02) mmol / L and LDL-C was (2.87 ± 1.27 ) mmol / L were significantly higher than those in the control group (4.95 ± 0.95), (1.75 ± 0.26), (3.01 ± 1.41) and (3.34 ± 1.48) mmol / L, respectively. The difference was statistically significant (P <0.05). The observation group patients did not appear during the treatment of statin-related adverse reactions, patients with better compliance, higher safety. Conclusion The treatment of coronary heart disease with statins combined with cardiovascular drugs has obvious therapeutic effect and high safety, which is worth to be popularized clinically.