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目的比较晚期胃癌中三种化疗方案的临床治疗效果和不良反应。方法选择淮阳县人民医院2013年8月至2014年8月期间收治的晚期胃癌患者32例,分成以亚叶酸钙、紫杉醇和草酸铂为主的3个化疗方案小组,比较三组方案的治疗效果和不良反应发生情况。结果亚叶酸钙组、紫杉醇组、草酸铂组总有效率分别为55.56%、58.33%、54.55%,三组化疗方案疗效比较差异未见统计学意义(P>0.05);三组方案的不良反应主要为外周神经毒性、胃肠道反应和脱发等,紫杉醇组与草酸铂组外周神经毒性比较差异有统计学意义(P<0.05),余差异均未见统计学意义(P>0.05)。结论三种化疗方案都是治疗晚期胃癌比较有效的方法,但相比之下,紫杉醇组治疗晚期胃癌的耐受性更好,患者的生活质量相对较高。
Objective To compare the clinical effects and adverse reactions of three chemotherapy regimens in advanced gastric cancer. Methods Thirty-two patients with advanced gastric cancer who were treated in Huaiyang County People’s Hospital from August 2013 to August 2014 were divided into three chemotherapy regimens which mainly consisted of leucovorin, paclitaxel and oxaliplatin. The treatment of three groups was compared Effects and adverse reactions occurred. Results The total effective rates of leucovorin group, paclitaxel group and oxaliplatin group were 55.56%, 58.33% and 54.55% respectively. There was no significant difference between the three groups in the curative effect of chemotherapy (P> 0.05). Adverse reactions Mainly peripheral neurotoxicity, gastrointestinal reactions and hair loss, paclitaxel group and oxaliplatin group peripheral neurotoxicity differences were statistically significant (P <0.05), the remaining differences were not statistically significant (P> 0.05). Conclusion All three chemotherapy regimens are effective in treating advanced gastric cancer. However, paclitaxel group is more tolerant to advanced gastric cancer and the quality of life of patients is relatively higher.