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目的探讨急性脑梗死患者B型利钠肽(BNP)及血浆肌钙蛋白(TNI)水平与预后的相关性。方法随机选择2014年1月至2015年1月急性脑梗死患者80例为脑梗死组,另选取同期短暂性脑缺血发作患者40例为脑缺血组。比较两组患者及不同梗死面积心功能指标水平。结果脑梗死组BNP检测水平高于脑缺血组,差异有统计学意义(P<0.05);TNI水平均为阳性,提示患者的临床预后较差,但两组比较差异未见统计学意义(P>0.05)。大面积脑梗死患者BNP水平高于脑缺血及中、小面积脑梗死者,差异有统计学意义(P<0.05)。表明BNP增加程度与脑梗死的面积呈正相关,BNP水平越高,预后越差。结论 BNP和TNI阳性提示脑梗死患者心肌损伤,需加强监护。
Objective To investigate the relationship between the levels of B-type natriuretic peptide (BNP) and plasma troponin (TNI) and prognosis in patients with acute cerebral infarction. Methods Totally 80 patients with acute cerebral infarction from January 2014 to January 2015 were selected as cerebral infarction group. Another 40 patients with transient ischemic attack were selected as cerebral ischemia group. The levels of cardiac function in two groups of patients and different infarct size were compared. Results The level of BNP in cerebral infarction group was higher than that of cerebral ischemia group (P <0.05). TNI level was positive, which indicated that the clinical prognosis was poor, but the difference was not statistically significant P> 0.05). BNP levels in patients with large area cerebral infarction were higher than those in cerebral ischemia and middle and small area cerebral infarction, the difference was statistically significant (P <0.05). This suggests that the increase of BNP is positively correlated with the area of cerebral infarction. The higher the BNP level, the worse the prognosis. Conclusions BNP and TNI positive suggest myocardial injury in patients with cerebral infarction, need to be intensively monitored.