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硝苯吡啶(Nifedipine)是一种钙通道拮坑剂。由于它对于具有兴奋性的组织的跨膜钙离子流有选择性的抑制作用,可导致冠状动脉和周围动脉的扩张,所以成功地用于治疗多种心血管疾患,尤其是对缺血性心脏病和系统性高血压的治疗。硝苯吡啶具有很强的系统血管扩张作用,从而使它在治疗左心衰竭的患者时,以其降低后负荷的作用而引人注目。硝苯吡啶能够阻滞心肌细胞的跨膜钙离子流的通透,因而发挥了直接的负性变力性作用,这一点有别于其他的血管扩张剂。
Nifedipine is a calcium channel antagonist. Because of its selective inhibitory effect on the transmembrane calcium flux in excitable tissues, which leads to the dilatation of coronary and peripheral arteries, it has been successfully used to treat a variety of cardiovascular conditions, particularly for ischemic heart Disease and systemic hypertension treatment. Nifedipine has a strong systemic vasodilator effect, making it attractive for the treatment of patients with left heart failure with its reduced postload effect. Nifedipine is able to block the permeation of transmembrane calcium flux in cardiomyocytes and thus exerts a direct, negative, force of variability unlike any other vasodilator.