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异烟阱的活性高,毒性低,很易透入脑脊液中,故为结核性脑膜炎化疗的主要药物。链霉素和乙胺丁醇仅在脑膜发炎时能较易透入,因而可保留在治疗的头6～8周内应用。在此期间给予25甚或45毫克/公斤/日乙胺丁醇是不会引起视神经炎的。看来,较大剂量可产生更有效的浓度。利福平在脑脊液中的浓度较血中低,这可能由于不与蛋白结合的、能透过正常脑膜的利福平浓度仅占其血浆总浓度之15％之故。其
Isofan trap high activity, low toxicity, easy to penetrate the cerebrospinal fluid, it is the main drug for tuberculous meningitis chemotherapy. Streptomycin and ethambutol are more permeable only when the meninges are inflamed, and thus remain available for the first 6 to 8 weeks of treatment. During this period given 25 or even 45 mg / kg / day ethambutol does not cause optic neuritis. It appears that larger doses produce more effective concentrations. Rifampicin in cerebrospinal fluid concentrations lower than the blood, which may be due to not protein binding, through the normal meningeal rifampicin concentrations accounted for only 15% of its total plasma concentration. its