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乙胺碘呋酮(AD)是含碘苯并呋喃的衍生物。临床上广泛用于治疗心绞痛及抗心律失常。但约26%的病人因副作用而停药。约有14～82%的病人服 AD 后血中肝酶类升高,重度肝损害者约占1～3%。作者对104例口服 AD 治疗超过两周的患者在治疗前及治疗后每4个月测定肝功能,所有死者均作肝组织学检查,以了解 AD 的肝脏毒性。结果 104例口服 AD 治疗者有25例(24%)血清转氨酶高于治疗前两倍或超过正常上限。其中3例发生肝损害的临床病征而停用 AD,停药后症状消失,肝酶恢复正常。余下22例随访了2～4个月,不管是否继续用药,肝酶异常消失。25例肝酶升高者中13
Amiodarone (AD) is a derivative of iodobenzofuran. Clinical widely used in the treatment of angina pectoris and anti-arrhythmia. However, about 26% of patients discontinued due to side effects. About 14 to 82% of patients with elevated blood enzymes of liver enzymes, severe liver damage accounted for about 1 to 3%. The authors tested 104 patients with oral AD for more than two weeks before and after treatment for liver function measurement every 4 months, and all deceased patients underwent liver histology to understand the liver toxicity of AD. Results Twenty-five (24%) of the 104 oral AD patients had higher serum aminotransferases than the previous two times or above the upper limit of normal. 3 cases of clinical symptoms of liver damage and disable AD, withdrawal symptoms disappeared, liver enzymes returned to normal. The remaining 22 patients were followed up for 2 to 4 months, with or without medication, abnormal liver enzymes disappear. 25 cases of liver enzymes increased in 13