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[目的 ]探讨对氨基水杨酸钠 (PAS Na)治疗慢性锰中毒的疗效。 [方法 ]根据GB 32 32 82诊断标准为锰中毒观察对象及慢性轻、重度锰中毒 5 2人的临床资料进行了回顾性分析 ,分为EDTA组、PAS组进行疗效对照观察。 [结果 ]两组经治疗后 ,PAS组症状和阳性体征较EDTA组改善明显 ,血锰水平降低较EDTA组明显 (P <0 0 1) ,但尿锰排出较ED TA组低 (P <0 0 5 ) ,PAS Na治疗后 4例患者脑脊液锰含量相当于治疗前脑脊液锰含量的 1 0～ 2 7 5倍 ,而血、尿锰均较治疗前明显下降。 [结论 ]PAS Na有明显的驱锰作用 ,脑脊液锰含量可作为慢性锰中毒生物监测的客观指标之一。
[Objective] To investigate the effect of sodium aminosalicylate (PAS Na) on chronic manganese poisoning. [Methods] According to the diagnostic criteria of GB 32 32 82, the clinical data of 52 patients with manganese poisoning and chronic mild or severe manganese poisoning were retrospectively analyzed and divided into EDTA group and PAS group for curative effect observation. [Results] After treatment, the symptom and the positive sign of PAS group were obviously improved compared with EDTA group, the blood manganese level was lower than that of EDTA group (P <0.01), but the urinary manganese excretion was lower than EDTA group (P <0 After treatment with PAS Na, the content of manganese in cerebrospinal fluid was equivalent to 10 ~ 257 times of that of cerebrospinal fluid before treatment, while the levels of blood and urine manganese were significantly lower than those before treatment. [Conclusion] PAS Na has a significant flooding effect on manganese, and the manganese content in cerebrospinal fluid can be used as one of the objective indicators for biological monitoring of chronic manganese poisoning.