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耳蜗外毛细胞具有主动运动性能的验证,展示了内耳生理学和病理生理学的一个新的侧面,关于耳蜗只是单纯被动地接受声波的概念显然应该扩充。更确切地说,最近的许多研究结论性地认为,内耳的外毛细胞可发生主动的机械性运动。主要依据是:(1)毛细胞内具有有收缩能力的分子,(2)耳蜗主动过程的推想,(3)外毛细胞及其皮板主动运动的直接显示。【外毛细胞中具有有收缩能力的分子】过去已在多种动物的毛细胞静纤毛中及皮板内发现了肌动蛋白及与其有关的分子,如肌球蛋白,α肌动蛋白,Fimbnn和原肌球蛋白等,并对其形态学特征作了详细描述。无论在肌细胞或非肌细胞内,上述蛋白均属与收缩运动有关的蛋白质。作者采用耳蜗毛细胞整体细胞解剖技术还可在特制的标本中显示完整的细胞支架。借助单克隆抗体技术,在免疫萤光显微镜下,除静纤毛
Cochlear outer hair cells with active motor performance verification, showing a new side of the inner ear physiology and pathophysiology, the concept of purely passive acceptance of sound waves on the cochlear apparently should be expanded. More specifically, many recent studies conclusively suggest that active hair mechanics occurs in the outer hair cells of the inner ear. The main basis is: (1) contractile molecules in hair cells, (2) cochlear projections of the proactive process, and (3) the direct display of the outer hair cells and their active motile. 【Molecules with Contraction in Outer Hair Cells】 Actin and its related molecules such as myosin, α-actin, Fimbnn And tropomyosin, etc., and its morphological characteristics were described in detail. Whether in muscle cells or non-muscle cells, the above proteins are contractile exercise-related proteins. Authors using cochlear hair cells as a whole cell dissection technique can also display a complete cell scaffold in a specially prepared specimen. With monoclonal antibody technology, immunofluorescence microscopy, except static cilia