肺泡表面活性物质作用的新学说——斥水模式

• 作 者: 朱小瑜 陈自励
• 机 构: 湖北省妇幼保健院新生儿科,湖北省妇幼保健院新生儿科,
• 出 处: 新生儿科杂志
• 发表日期: 1987年01期
• 关键词: 新学说 肺表面活性物质 肺泡腔 表面张力 卵磷脂 棕榈 生理作用 bubble 肺泡萎陷 气体交换

早在40年前,人们就从肺组织中提取了双棕榈酰卵磷脂(dipalmitoyl lecithin,DPL),并认为是肺表面活性物质的主要成分,其主要生理作用是减低肺泡表面张力,减轻呼吸时扩张肺泡需要克服的阻力和阻止因表而张力液体易于吸入肺泡腔的倾向。这一传统理论,久被国内外所公认,称水泡模式(bubble model)。近年来,美国Texas大学Hills教授等

As early as 40 years ago, people extracted dipalmitoyl lecithin (DPL) from the lung tissue and considered it as the main component of pulmonary surfactant. Its main physiological function is to reduce the surface tension of the alveoli and reduce the respiratory rate Expansion of alveolar need to overcome the resistance and to prevent the surface tension of the fluid tends to be inhaled into the alveolar space tendency. This traditional theory has long been recognized at home and abroad as the bubble model. In recent years, the United States University Hills professor and so on