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目的探讨胃肠道间质瘤中Bax表达与生物学行为的关系。方法运用免疫组织化学SP法检测Bax在胃肠道间质瘤中的表达情况,并分析其在良性、潜在恶性、恶性瘤组织中的表达差异。结果55例胃肠道间质瘤中,33例(60.0%)Bax阳性表达。Bax在良性胃肠道间质瘤中表达较低(28.6%),而潜在恶性和恶性胃肠道间质瘤中Bax表达显著增高,分别达71.4%、70.3%。良性与潜在恶性、良性与恶性胃肠道间质瘤之间Bax的阳性表达率差异有统计学意义(P<0.05),但潜在恶性和恶性胃肠道间质瘤之间的Bax阳性表达率差异无统计学意义(P>0.05)。Bax的表达与患者的性别、年龄、部位、肿瘤大小、有无坏死及组织学分型无关。结论Bax检测可作为预测胃肠道间质瘤恶性潜能的重要参考指标。
Objective To investigate the relationship between Bax expression and biological behavior in gastrointestinal stromal tumors. Methods The expression of Bax in gastrointestinal stromal tumors was detected by immunohistochemical SP method, and its expression in benign, potentially malignant and malignant tumors was analyzed. Results Among 55 cases of gastrointestinal stromal tumors, 33 cases (60.0%) had positive expression of Bax. Bax expression was lower in patients with benign gastrointestinal stromal tumors (28.6%), while the expression of Bax was significantly higher in potentially malignant and malignant gastrointestinal stromal tumors (71.4% and 70.3%, respectively). The positive expression rates of Bax in benign and potentially malignant, benign and malignant gastrointestinal stromal tumors were significantly different (P <0.05), but the positive rates of Bax expression between potentially malignant and malignant gastrointestinal stromal tumors The difference was not statistically significant (P> 0.05). Bax expression and the patient’s gender, age, location, tumor size, with or without necrosis and histological type has nothing to do. Conclusion Bax detection can be used as an important reference index for predicting the malignant potential of gastrointestinal stromal tumors.