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细胞外基质（Ｅｘｔｒａｃｅｌｕｌａｒｍａｔｒｉｘ，ＥＣＭ）是肿瘤浸润转移的自然屏障，主要有基底膜和间质结缔组织两种结构［１］。基底膜为一连续的无细胞结构，层粘连蛋白（Ｌａｍｉｎｉｎ，ＬＮ）及Ⅳ型胶原（ＣｏｌａｇｅｎｔｙｐｅⅣ，ＣｏｌⅣ）是基底膜的重要...
Extracelular matrix (ECM) is a natural barrier to invasion and metastasis of tumors. It mainly consists of two types of structures, the basement membrane and the connective tissue of the interstitium [1]. The basement membrane is a continuous cell-free structure, laminin (LN) and collagen type IV (Colagentype IV, ColIV) are important for the basement membrane...