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目的:探讨临床指标与气道炎症标志物对预示慢性阻塞性肺疾病(COPD)病情的临床价值。方法:抽取2014年1月-2015年1月清远市清城区石角镇卫生院治疗的60例COPD患者,将其按照疾病程度分为中度组与重度组,每组各30例,观察两组患者治疗前后各项指标变化情况。结果:治疗后,两组患者每日痰量及圣乔治呼吸调查问卷(SGRQ)评分明显低于治疗前,差异具有统计学意义(P<0.05);治疗后,两组患者肺功能明显优于治疗前,差异具有统计学意义(P<0.05);治疗后,两组患者血氧分压(Pa O2)明显上升,血二氧化碳分压(Pa CO2)明显下降,血气得到改善,差异具有统计学意义(P<0.05);治疗后,两组患者血清CRP及血清IL-8水平明显低于治疗前,差异具有统计学意义(P<0.05);重度组血清C反应蛋白(CRP)及血清白介素8(IL-8)水平治疗后明显高于中度组,差异具有统计学意义(P<0.05)。结论:SGRQ、气道炎症指标(CRP、IL-8)能有效地证实COPD病情演变过程,能准确判断疾病发展过程,为疾病的判断提供有效的参考依据。
Objective: To investigate the clinical value of clinical indicators and markers of airway inflammation in predicting the status of chronic obstructive pulmonary disease (COPD). Methods: From January 2014 to January 2015, 60 patients with COPD were treated in Shijiao Town Health Care Hospital, Qingcheng District, Qingyuan City. The patients were divided into moderate and severe COPD groups according to the degree of disease, with 30 cases in each group. Group before and after treatment of various indicators of changes. Results: After treatment, the daily sputum volume and St. George’s Respiratory Questionnaire (SGRQ) scores of the two groups were significantly lower than those before treatment (P <0.05); after treatment, the lung function of the two groups was significantly better than Before treatment, the difference was statistically significant (P <0.05). After treatment, PaO2 significantly increased, Pa CO2 decreased significantly, blood gas was improved, the difference was statistically significant (P <0.05). After treatment, the levels of serum CRP and serum IL-8 in the two groups were significantly lower than those before treatment (P <0.05). Serum C-reactive protein (CRP) and serum interleukin 8 (IL-8) levels after treatment were significantly higher than the moderate group, the difference was statistically significant (P <0.05). CONCLUSION: SGRQ and airway inflammation index (CRP, IL-8) can effectively confirm the evolution of COPD and accurately determine the process of disease development, and provide an effective reference for disease judgment.