论文部分内容阅读
目的探讨低度恶性腹膜囊性间皮瘤(LGMCMP)的临床病理特征及预后。方法分析25例LGMCMP的临床病理特征及免疫组织化学和电镜结果,结合临床随访资料评价治疗效果与预后。结果25例中女性18例,男性7例,平均年龄39.6岁(16~84岁)。大体形态有3种类型,即局限囊性肿块型、多发性囊性结节型及弥漫性囊性结节型。免疫组织化学肿瘤细胞对CK、Vim-entin、EMA及抗间皮细胞抗原均呈阳性表达。组织化学25例CI染色均呈不同阳性,而HCI染色则均呈阴性。电镜11例瘤细胞表面均见较多细长微绒毛,并见大量张力微丝及桥粒。结论LGMCMP是一种好发中年女性的具有低度恶性的少见肿瘤,具有独特临床的及病理形态特征。
Objective To investigate the clinicopathological features and prognosis of low-grade malignant peritoneal cystic mesothelioma (LGMCMP). Methods The clinicopathological features, immunohistochemical and electron microscopy results of 25 cases of LGMCMP were analyzed. Clinical outcomes and prognosis were evaluated by clinical follow-up data. Results Among the 25 cases, there were 18 females and 7 males with an average age of 39.6 (16-84 years). There are three types of gross morphology, namely confined cystic mass type, multiple cystic nodular type, and diffuse cystic nodular type. Immunohistochemical tumor cells showed positive expression of CK, Vim-entin, EMA and anti-mesothelial cell antigens. Histochemical staining showed positive staining in 25 cases of CI and negative staining in HCI. Electron microscopy showed that there were more slender microvilli on the surface of tumor cells in 11 cases, and a large number of tension microfilaments and desmosomes were seen. Conclusion LGMCMP is a rare malignant tumor of middle-aged women with unique clinical and pathological features.