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清醒大鼠侧脑室内注入红藻氨酸后,在海马内发现了正性、负性及无关单位等三种单位电反应。大多数正性单位来源于组织学上与海马锥体细胞相对应的海马复合峰电位细胞;同时,大多数海马复合峰电位细胞在注入红藻氨酸后表现为正性单位的放电形式。在注入红藻氨酸后的早期,正性单位主要集中于CA_3区。本文推测;(1)正性单位可能是红藻氨酸引起海马神经元癫痫样电活动的典型表现;负性单位的放电特征可能是其受海马中间抑制性神经元活动影响或是其过度去极化的结果;(2)海马内的锥体细胞比中间神经元对红藻氨酸的致癫作用更为敏感,CA_3区内的某些锥体细胞可能在红藻氨酸致癫过程中起着“起搏细胞”的作用。
After conscious rats were injected with kainic acid into the lateral ventricle, three kinds of unit reactions, positive, negative and unrelated, were found in the hippocampus. Most of the positive units originated from hippocampal complex-spike cells histologically corresponding to hippocampal pyramidal cells. Meanwhile, most of the hippocampal complex-spiking cells showed positive units of discharge after the injection of kainic acid. In the early after injection of kainic acid, positive units mainly concentrated in CA_3 area. This article speculates that: (1) positive units may be kainic acid-induced electrical activity of epileptiform hippocampal neurons in the typical performance; negative unit discharge characteristics may be affected by its inhibitory neurons in the hippocampus activity or excessive (2) The pyramidal cells in the hippocampus are more sensitive to the epileptic effects of kainic acid than the interneurons. Some of the pyramidal cells in the CA 3 region may be involved in the process of epilepsy induced by kainate Play a “paced cell” role.