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目的了解医院严重药品不良反应发生特性,分析其影响因素,为临床安全用药提供参考。方法对医院2015年上报的110例严重(含新的严重的)药品不良反应报告进行回顾性分析。结果抗肿瘤药发生的不良反应最多,其次为抗感染药;静脉滴注为主要用药方式;不良反应主要为骨髓毒性,表现为白细胞减少、血小板减少、红细胞减少和血红蛋白含量降低等。结论应加强临床医护人员对严重药品不良反应的认识和培训,提高严重药品不良反应的上报率,深入分析、评价报表,保障临床安全用药。
Objective To understand the characteristics of hospital serious adverse drug reactions, analyze its influencing factors and provide reference for clinical safety medication. Methods A retrospective analysis was made on 110 cases of serious (including severe new) adverse drug reactions reported by the hospital in 2015. Results The antitumor drugs had the most side effects, followed by the anti-infective drugs. The intravenous drip was the main method of medication. The main adverse reactions were myelotoxicity, including leukopenia, thrombocytopenia, erythrocyte reduction and hemoglobin content reduction. Conclusion Clinicians should enhance awareness and training of serious adverse drug reactions, raise the reporting rate of serious adverse drug reactions, and further analyze and evaluate reports to ensure clinical safety.