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目的评价玻璃体内注射曲安奈德(TA)治疗黄斑水肿的疗效和安全性。方法 23例黄斑水肿患者经玻璃体内注射TA后定期随访6个月,对比观察用药前后的视力、眼压、眼底荧光造影以及OCT检测的黄斑区视网膜厚度变化。结果所有患者治疗后最佳矫正视力均比术前不同程度提高。OCT测量黄斑区视网膜厚度,治疗前后相比有统计学差异(P<0.01)。6眼在注射药物后出现不同程度的高眼压。结论玻璃体内注射TA短期内能有效改善黄斑水肿和明显提高视力,其长期疗效和安全性尚需进一步评价。
Objective To evaluate the efficacy and safety of intravitreal triamcinolone acetonide (TA) in the treatment of macular edema. Methods Twenty-three patients with macular edema were followed up for 6 months after intravitreal injection of TA. The visual acuity, intraocular pressure, fundus fluorescein angiography and macular retinal thickness measured by OCT were compared before and after treatment. Results All patients after treatment, the best corrected visual acuity improved to varying degrees than before surgery. OCT macular retinal thickness measured before and after treatment compared to a statistically significant difference (P <0.01). Six eyes showed different degrees of intraocular hypertension after the injection of drugs. Conclusion Intravitreal injection of TA shortly can effectively improve macular edema and improve visual acuity. Its long-term efficacy and safety need further evaluation.